| Away | Home | Model Pick | Confidence | |
| Atlanta | @ | Miami | Miami +106 | Low |
| Cleveland | @ | Detroit | Cleveland -132 | Low |
| Cincinnati | @ | Philadelphia | Cincinnati +105 | High |
| Baltimore | @ | Tampa Bay | Tampa Bay -118 | High |
| NY Mets | @ | Washington | Washington +122 | Low |
| Toronto | @ | NY Yankees | NY Yankees -124 | High |
| Milwaukee | @ | Chi Cubs | Chi Cubs +104 | Low |
| Boston | @ | Kansas City | Kansas City +114 | Low |
| Houston | @ | Minnesota | Minnesota -145 | High |
| Pittsburgh | @ | St. Louis | St. Louis -104 | Low |
| Texas | @ | Colorado | Colorado +106 | Low |
| Sacramento | @ | LA Angels | LA Angels -145 | Low |
| Chi Sox | @ | Seattle | Seattle -155 | Low |
| LA Dodgers | @ | San Diego | San Diego +134 | Low |
| SF Giants | @ | Arizona | SF Giants +105 | Low |