| Away | Home | Model Pick | Confidence | ||
| Houston | @ | Chi Cubs | Chi Cubs -132 | Low | |
| St. Louis | @ | Cincinnati | St. Louis +100 | Low | |
| Cleveland | @ | Philadelphia | Cleveland +158 | High | |
| Tampa Bay | @ | NY Yankees | Tampa Bay +130 | High | |
| Pittsburgh | @ | Toronto | Pittsburgh +138 | High | |
| Minnesota | @ | Boston | Minnesota +130 | Medium | |
| NY Mets | @ | Miami | Miami +105 | Low | |
| Detroit | @ | Baltimore | Detroit +105 | High | |
| Washington | @ | Atlanta | Washington +156 | Medium | *Confirm Pitcher |
| Seattle | @ | Kansas City | Kansas City +118 | Medium | |
| LA Dodgers | @ | Milwaukee | Milwaukee -115 | High | |
| Texas | @ | LA Angels | LA Angels +148 | Low | |
| Sacramento | @ | San Diego | San Diego -118 | Low | |
| Colorado | @ | Arizona | Arizona -190 | Low | |
| Chi Sox | @ | SF Giants | SF Giants +100 | Low |