| * Probable Pitcher (not confirmed) | ||||||||
| **Expected to get bulk of innings | ||||||||
| Away | Pitcher | Win % | Fair Odds | Home | Pitcher | Win % | Fair Odds | |
| Houston | Arrighetti | 40.7% | +146 | @ | Chi Cubs | Taillon | 59.3% | -146 |
| St. Louis | Leahy | 51.9% | -108 | @ | Cincinnati | Paddack | 48.1% | +108 |
| Cleveland | G Williams | 46.5% | +115 | @ | Philadelphia | Sanchez | 53.5% | -115 |
| Tampa Bay | Martinez | 52.3% | -110 | @ | NY Yankees | Cole | 47.7% | +110 |
| Pittsburgh | Chandler | 50.5% | -102 | @ | Toronto | Gausman | 49.5% | +102 |
| Minnesota | Prielipp | 50.3% | -101 | @ | Boston | Tolle | 49.7% | +101 |
| NY Mets | Myers | 45.3% | +121 | @ | Miami | E Perez | 54.7% | -121 |
| Detroit | Flaherty | 52.6% | -111 | @ | Baltimore | Bassitt | 47.4% | +111 |
| Washington | Mikolas | 53.5% | -115 | @ | Atlanta | *Elder | 46.5% | +115 |
| Seattle | Gilbert | 51.3% | -105 | @ | Kansas City | Cameron | 48.7% | +105 |
| LA Dodgers | Wrobleski | 45.3% | +121 | @ | Milwaukee | Henderson | 54.7% | -121 |
| Texas | deGrom | 53.8% | -117 | @ | LA Angels | G Rodriguez | 46.2% | +117 |
| Sacramento | Springs | 48.0% | +108 | @ | San Diego | Buehler | 52.0% | -108 |
| Colorado | Sugano | 38.4% | +160 | @ | Arizona | Soroka | 61.6% | -160 |
| Chi Sox | Martin | 45.3% | +121 | @ | SF Giants | McDonald | 54.7% | -121 |