| Away | Home | Model Pick | Confidence | ||
| Houston | @ | Chi Cubs | Chi Cubs -140 | Low | |
| St. Louis | @ | Cincinnati | St. Louis +100 | Medium | |
| Cleveland | @ | Philadelphia | Cleveland +158 | High | |
| Tampa Bay | @ | NY Yankees | Tampa Bay +136 | Low | |
| Pittsburgh | @ | Toronto | Pittsburgh +140 | High | |
| Minnesota | @ | Boston | Boston -148 | Low | |
| NY Mets | @ | Miami | Miami -112 | High | |
| Detroit | @ | Baltimore | Detroit +118 | High | |
| Washington | @ | Atlanta | Atlanta -224 | Low | *Confirm Pitcher |
| Seattle | @ | Kansas City | Seattle -130 | Low | |
| LA Dodgers | @ | Milwaukee | Milwaukee -104 | Low | |
| Texas | @ | LA Angels | Texas -164 | Medium | |
| Sacramento | @ | San Diego | San Diego -126 | Low | |
| Colorado | @ | Arizona | Arizona -190 | Low | |
| Chi Sox | @ | SF Giants | SF Giants -105 | Low |