| * Probable Pitcher (not confirmed) | ||||||||
| **Expected to get bulk of innings | ||||||||
| Away | Pitcher | Win % | Fair Odds | Home | Pitcher | Win % | Fair Odds | |
| Houston | Arrighetti | 36.2% | +176 | @ | Chi Cubs | Taillon | 63.8% | -176 |
| St. Louis | Leahy | 51.9% | -108 | @ | Cincinnati | Paddack | 48.1% | +108 |
| Cleveland | G Williams | 43.0% | +133 | @ | Philadelphia | Sanchez | 57.0% | -133 |
| Tampa Bay | Martinez | 49.6% | +102 | @ | NY Yankees | Cole | 50.4% | -102 |
| Pittsburgh | Chandler | 40.3% | +148 | @ | Toronto | Gausman | 59.7% | -148 |
| Minnesota | Prielipp | 34.5% | +190 | @ | Boston | Tolle | 65.5% | -190 |
| NY Mets | Myers | 36.0% | +177 | @ | Miami | E Perez | 64.0% | -177 |
| Detroit | Flaherty | 44.6% | +124 | @ | Baltimore | Bassitt | 55.4% | -124 |
| Washington | Mikolas | 32.5% | +207 | @ | Atlanta | *Elder | 67.5% | -207 |
| Seattle | Gilbert | 55.8% | -126 | @ | Kansas City | Cameron | 44.2% | +126 |
| LA Dodgers | Wrobleski | 48.1% | +108 | @ | Milwaukee | Henderson | 51.9% | -108 |
| Texas | deGrom | 68.1% | -214 | @ | LA Angels | G Rodriguez | 31.9% | +214 |
| Sacramento | Springs | 39.7% | +152 | @ | San Diego | Buehler | 60.3% | -152 |
| Colorado | Sugano | 34.6% | +189 | @ | Arizona | Soroka | 65.4% | -189 |
| Chi Sox | Martin | 45.3% | +121 | @ | SF Giants | McDonald | 54.7% | -121 |